Interesting places in the park include the Rufiji River, which flows into the Indian Ocean opposite Mafia Island and the Stiegler Gorge, a canyon of 100 metres depth and 100 metres width. Habitats include grassland, typical Acacia savanna, wetlands and extensive Miombo woodlands. Although total wildlife populations are high, the reserve is large and densities of animals are lower than in the more regularly visited northern tourist circuit of Tanzania.
Walking safaris are permitted in the Selous, and boat trips on the Rufiji are a popular activity. A boundary change to allow the use of uranium deposits has been approved. The approval for the boundary change was given by the UNESCO and seriously criticized by environmentalists and organizations.